Returning to Daisy Town one day, Luke finds the town deserted. The town folk are at the cemetery, attending Luke's own funeral. A new sheriff comes to town to take over Luke's place. Sweating, Luke wakes up and finds himself in the middle of the desert, bitten by a snake. His horse Jolly Jumper runs to town for help and Lotta Legs must find Luke and an antidote fast! The Daltons try to stop her...